Learn how the
multimode source for the Agilent LC/MSD quadrople system
produces ions simultaneously under ESI and APCI conditions, thereby eliminating the step of reanalyzing samples.
| E-seminar Description |
Simultaneous ESI and APCI on an LC/MSD Quadrupole System
Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are the two ionization techniques most commonly used in LC/MS. A large percentage of analytes will ionize by either technique, yielding useful information. However, some analytes produce ions by only one of the techniques. Furthermore, in applications involving the analysis of unknowns or compounds whose structure is tentative, e.g., drug discovery, it may not clear which ionization technique to use, or some components of the sample may not respond in the ionization mode that was chosen. In these instances, if no response is obtained using ESI (for instance), the samples must then be reanalyzed using APCI in an attempt to obtain the additional information. This re-analysis step seriously impacts the throughput of the laboratory. The recently developed "multimode" ion source for the Agilent LC/MSD quadrupole system produces ions simultaneously under ESI and APCI conditions, thereby eliminating the step of reanalyzing samples. It also operates at HPLC flow rates, up to 2 mL/minute, typical of high throughput analyses. A description of the multimode source, its operation and performance, and comparisons with dedicated ESI and APCI sources will be presented |
| Date/Time |
Available as recorded event
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