Online literature is provided as Adobe Acrobat Portable Document Format (PDF) files. Obtain your free copy of the current Acrobat Reader from Adobe Systems.

Creating and Using a Performance-Based LC/MSD Mass Spectral Library with NIST MS Search Software

Abstract: Currently, due to the different tune requirements, instrument parameters, and hardware differences, universal liquid chromatography/mass spectrometry libraries do not exist as they do for gas chromatography/mass spectrometry electron impact systems. However, using performance-based tune criteria for instruments, consistent and reproducible spectra can be obtained. This is the concept for creating universal searchable liquid chromatography/mass spectrometry libraries. This application note shows step-by-step procedures for tuning the liquid chromatography/mass selective detector (LC/MSD) to performance-based criteria, for creating a spectral library, and for searching the library. A mass spectral library developed under the performance-based conditions can be used on any LC/MSD tuned to performance-based criteria.

View Article (1.70 MB)

For your convenience this PDF file will open in a separate window, and you may need to adjust your pop up blocker setting.