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Predictable Translation of Capillary Gas Chromatography Methods for Fast GC

Abstract: The time required for capillary gas chromatography (GC) runs is often the major factor in sample turnaround time. Fast GC can significantly improve laboratory productivity by decreasing analysis time. However, converting established capillary GC methods to fast GC can be a daunting task. The Agilent GC method translation software is a freeware program that logically and predictably translates traditional capillary GC methods. The translation program preserves the elution order for each compound, so that identification of each peak does not have to be repeated. Validation for the new method is made easier. The method translation software will instantly calculate temperature and flow conditions to meet various requirements including retention time locking, best theoretical efficiency, and decreased time. This application note discusses considerations involved in choosing fast GC over conventional GC, describes the Agilent GC method translation software, and demonstrates translating methods for faster analysis of solvents, styrene monomers, reformate gasoline, hydrocarbon emissions, semivolatile mixtures, and a chemical process intermediate.

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