Mass Spectrometry 

LC/MS Instruments 

6400 Series Triple Quadrupole LC/MS 
Product Description
Meet your quantitative needs with triple quadrupole performance which gives  superior sensitivity, renowned performance reliability, and easy upgradeability. The Agilent 6400 Series Triple Quadrupole LC/MS Systems are the proven choice for your quantitative applications in pharmaceutical ADME/DMPK studies, biomarker validation, clinical research, food safety, forensics, toxicology, and environmental analyses.

Choose an Agilent 6420, 6460, or 6490 Triple Quadrupole LC/MS System for unmatched productivity, performance, and value for all your quantitative analysis needs. The 6420 is economical and easy to use – a perfect workhorse instrument for laboratories requiring standard quantitative capabilities. The 6460 adds Agilent Jet Stream (AJS) technology to dramatically increase sensitivity for a wide range of challenging quantitative applications. The 6490 includes novel iFunnel technology for ultra-trace analysis – with attogram limits of quantitation and an unprecedented six orders of linearity for your most demanding quantitative analyses.

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  • Achieve the highest sensitivity – iFunnel technology dramatically increases ion sampling and transmission, enabling the lowest limits of detection and quantitation for your most demanding applications.
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation.
  • Automate compound optimization – MassHunter Optimizer software automatically optimizes MRM transitions and fragmentor and collision energies for both small molecules and peptides.
  • Higher scan speed – fast scan speeds allow you to take full advantage of today’s high throughput UHPLC chromatography.   
  • Ultra fast MRM acquisition speeds and ion polarity switching – An innovative collision cell eliminates cross-talk and enables 1ms MRM dwell times, together with fast polarity switching, ensures compatibility with UHPLC analyses.
  • Streamline method development – Dynamic MRM (dMRM) simplifies method development and allows thousands of compounds to be quantified in a single method with optimal sensitivity and reproducibility.
  • Compatibility with a wide range of ionization sources – ESI, AJS, APCI, APPI, Multi-mode sources, and innovative HPLC-Chip technology for robust and ultra-sensitive quantitation with small sample volumes. 
  • Comprehensive and easy-to-use MassHunter Workstation software dramatically enhances productivity from method optimization, data acquisition to data processing and reporting.
                  Partner with Agilent

                  Instrument performance and maintenance is vital to your success in the laboratory and with Agilent’s training, instrument service plans, or on-demand repair services, you will achieve reliable and accurate results with maximum instrument uptime. We understand that optimal performance is mission-critical to your productivity and you can depend on Agilent to be there when you need us. With Agilent, you can be confident that you not only have the best instrument for the job, but also the best partner for the future.

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                • Software

                  MassHunter software - instrument control, data acquisition and processing, reporting

                  Mass Profiler Professional - statistical and differential analysis of multiple sample groups

                  LC/MS Series Systems

                  6100 Series Quadrupole LC/MS Systems

                  6400 Series Triple Quadrupole LC/MS Systems

                  6200 Series Accurate-Mass TOF LC/MS Systems


                  Mass Spec Work Bench

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