Liquid Chromatography 

Extended LC Systems & Workflow Solutions 

1260 Infinity Analytical SFC System 
Product Description
The 1260 Infinity Analytical SFC system is an easy-to-use SFC system for chiral and a-chiral separations, providing LC-like sensitivity and UHPLC power range. Unique SFC/UHPLC switching capability with the SFC/UHPLC Hybrid system provides two orthogonal separation modes in one single system. This enables intelligent screening for the best suitable method and delivers comprehensive information for complex samples and impurity analysis. The Agilent 1260 SFC solution include the broadest and most versatile SFC price/performance range - from simple SFC upgrades to pre-existing 1100/1200/1260 LC systems to full SFC/UHPLC/MS solutions.
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Typical performance of the 1260 Infinity Analytical SFC system
Important information for customers of Aurora SFC Systems

View related Application Notes and Technical Overviews using the Application Finder.
  • Available as complete system or as upgrade to existing Agilent 1100, 1200 and 1260 LC systems
  • Unique switching capability between UHPLC/SFC in a single system without equilibration
  • Only SFC system with 600 bar capability
  • Different solvent selection choices for a wide range of organic modifiers to exploit unique selectivity
  • UHPLC-like sensitivity
  • Ten - to fifteen fold lower operating costs by using standard grade gaseous CO2
  • Optional full method development features available for fast, straightforward column and modifier selection
  • MS compatibility with the Agilent 6100 Series Single Quadrupole LC/MS systems
  • Low solvent consumption and less waste generation for true green chemistry
  • Agilent instrument and service quality
  • Ordering Details
  • Feature Specification
    Flow range 0.1 mL/min to 5 mL/min (settable), 1 mL to 5 mL/min recommended
    Maximum operating pressure 600 bar
    Upgrade possibility of existing 1100/ 1200 / 1260 LC yes
    Option for SFC/ UHPLC in one system yes
    CO2 purity requirements 99.99% for gas, 99.999% for liquid
    Unattended operation Leak sensors, diagnostic software features
    Fusion A5 SFC Module  
    backpressure accuracy +/- 1%
    Backpressure precision +/- 0.5 bar (+/-0.2 bar typical)
    Backpressure thermal precision +/- 1C
    Chiller temperature -20C to  9 C
    Number of co-solvents 1, with SSV pump option 3, with external SSV 12
    Precision of flow rate  Same as G1312B, ≤0.07 % RSD or ≤0.02 min SD, whatever is greater based on retention time at constant room temperature
    Precision of composition Same  As G1312B, < 0.15 % RSD or < 0.04 min SD whatever is greater
    Number of samples 100 x 2 mL vials, 30 x 6 mL vials
    Injection volume 5 uL for  full loop injections (5 uL loop as default) larger loops possible (10uL), partial loop filling for smaller injection volumes
    Injection principle Fixed loop
    Injection precision <0.3% RSD for 5 ul
    Sample temperature control 4-40C with sample thermostat
    Sample carryover 0.05%
    Column compartment (TCC)  
    Column Up to 300 mm length x 4.6 mm ID (or less)
    Column capacity Up to 3, with additional 2x TCCs up to 9
    Switching valve Optional (2/6, 2/10, 8/9, 6 column selector)
    Temperature range Ambient -10C to 100 C
    Column compartement temperature accuracy +/- 0.5C
    Column compartement temperature stability +/- 0.05C
    Active solvent pre-heating and post-conditioning As standard
    Automated Method development optional
    Wave length range 190-950 nm
    Wavelenghth accuracy +/- 1 nm
    Linearity range 2.0 AU @ 265 nm
    Noise, wet +/- 0.05 mAU under SFC conditions at 254 nm 20% MetOH/80% CO2 +/- 0.007 mAU under LC condition
    Drift 0.9 mAU/hr
    Data rate 80 Hz
    Cell pressure limit 400 bar
    Cell path length 10 mm
    Cell volume 13 ul
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