Liquid Chromatography 

1220 Infinity LC Systems 

1220 Infinity LC System 
Product Description
Infinitely more affordable
The Agilent 1220 Infinity LC System is an affordable, high quality UHPLC system for routine standard analyses that maximizes uptime, minimizes maintenance and provides the highest return on your investment. As a member of the 1200 Infinity Series it gives you the proven quality and performance you expect from the industry leader, in your choice of four easy to own, integrated, "all-in-one" configurations. The new 1220 Infinity LC with integrated diode-array detector can also be used for mobile applications

View related Application Notes and Technical Overviews using the Application Finder.
  • Winner of the Scientists’ Choice Award as Best New Separations Product of 2010.
  • Optimized for everyday productivity - exceptional accuracy and superior precision for all routine applications
  • Fully compliant with all requirements for regulatory LC applications.
  • Industry leading quality and long-life - a member of the reliable and trusted 1200 Infinity Series.
  • Fast, trouble-free startup - every system is tested in its final configuration.
  • Flexibility - hardware choices and all-in-one configurations include an isocratic or gradient pump, manual injector or vial autosampler, column oven and variable wavelength detector.
  • Future proof - upgrade your system with additional hardware modules such as a 1200Infinity Series refractive index, fluorescence or evaporative light scattering detector, or a 6000 Series Single Quadrupole MS.
  • Higher resolution and faster run times - our optimized pump delivers up to 600 bars so you can use smaller particle size columns.
  • High pressure capabilities - get up to 600 bars from our integrated autosampler and manual injector.
  • Lower detection limits using a variable wavelength detector up to 80 Hz.
  • Maintain stable temperatures with the optional column oven.
  • High performance software - chose either OpenLAB EZChrom Edition or the fully flexible, multi-purpose OpenLAB ChemStation Edition.
  • Ordering Details 
  • Software and Informatics
  • Agilent 1220 Infinity LC System - Performance Specifications
    Safety features Extensive diagnostics, error detection and display, leak detection, safe leak handling, leak output signal for shutdown of pumping system. Low voltages in major maintenance areas.
    Control and data evaluation Agilent EZChrom Compact, Agilent Lab Advisor, Agilent ChemStation, Agilent EZChrom Elite
    Communications Controller-area network (CAN), RS-232C, APG Remote: ready, start, stop and shut-down signals, LAN
    GLP features Early maintenance feedback (EMF), electronic records of maintenance and errors

    Agilent 1220 Infinity LC System – Performance Specifications Pumps (isocratic and gradient)
    Hydraulic system Dual plunger in series pump with proprietary servo-controlled variable stroke drive, floating plungers and passive inlet valve
    Settable flow range 0.001 – 10 mL/min, in 0.001 mL/ min increments
    Flow range 0.2 – 10.0 mL/min
    Flow precision <0.07% RSD, or < 0.02 min SD whatever is greater, based on retention time at constant room temperature
    Flow accuracy ± 1% or 10 μl/min whatever is greater
    Pressure Operating range 0 – 60 MPa (0 – 600 bar, 0 – 8700 psi) up to 5 mL/min
    Operating range 0 – 40 MPa (0 – 400 bar, 0 – 5880 psi) up to 5 mL/min
    Operating range 0 – 20 MPa (0 – 200 bar, 0 – 2950 psi) up to 10 mL/min (all versions)
    Pressure pulsation < 2 % amplitude (typically < 1 %), at 1 mL/min isopropanol, at all pressures > 1 MPa (10 bar)
    Compressibility compensation User-selectable, based on mobile phase compressibility
    Recommended pH range 1.0 – 12.5, solvents with pH < 2.3 should not contain acids which attack stainless steel
    Gradient formation (gradient pump or optional; two solvents) Low pressure dual mixing/gradient capability using proprietary high-speed proportioning valve
    Pump delay volume 600 – 900 μl, system delay volume 800 – 1100 μl, dependent on back pressure
    Composition range 0 – 95 % or 5 – 100 %, user selectable
    Composition precision < 0.2 % RSD or < 0.04 min SD, whatever is greater, at 1 mL/min; based on retention time at constant room temperature

    Agilent 1220 Infinity LC System Performance Specifications – Integrated degassing unit (gradient pump only)
    Maximum flow rate 10 mL/ min per channel
    Number of channels 2
    Internal volume 1.5 mL/ channel

    Agilent 1220 Infinity LC System - Performance Specifications Autosampler
    Pressure Operating range 0 – 60 MPa (0 – 600 bar, 0 – 8700 psi)
    Injection range 0.1 – 100 μL in 0.1 μL increments
    Up to 1500 μL with multiple draw (hardware modification required)
    Replicate injections 1 – 99 from one vial
    Precision < 0.25% RSD from 5 – 100 μL, < 1% RSD 1 – 5 μL variable volume
    Minimum sample volume 1 μL from 5 μL sample in 100 μL microvial, or 1 μL from 10 μL sample in 300 μL microvial
    Carryover Typically < 0.1%, < 0.05% with external needle cleaning
    Sample viscosity range 0.2 – 50 cp
    Sample capacity 100 × 2-mL vials in 1 tray
    40 × 2-mL vials in ½ tray
    15 × 6-mL vials in ½ tray (Agilent vials only)
    Injection cycle time Typically 50 s depending on draw speed and injection volume

    Agilent 1220 Infinity LC System - Performance Specifications Oven
    Temperature range 5 °C above ambient to 80 °C
    Temperature stability ± 0.15 °C
    Temperature accuracy ± 0.8 °C with calibration ± 0.5 °C
    Column capacity One 25-cm column
    Internal volume 6 μL

    Agilent 1220 Infinity LC System Performance Specifications Variable Wavelength Detector
    Detection type Double-beam photometer
    Light source Deuterium lamp
    Wavelength range 190 – 600 nm
    Short term noise ± 0.35 × 10-5 AU, at 230 nm
    Drift 3 × 10-4 AU/hr, at 254 nm
    Linearity > 2 AU (5%) upper limit
    Wavelength accuracy ± 1 nm; Self-calibration with deuterium lines, verification with holmium oxide filter
    Band width 6.5 nm typical
    Flow cells Standard: 14- μL volume, 10-mm cell path length and 40 bar (588 psi) pressure maximum
    High pressure: 14- μL volume, 10-mm cell path length and 400 bar (5880 psi) pressure maximum
    Semi-micro: 5- μL volume, 6-mm cell path length and 40 bar (588 psi) pressure maximum

    Agilent 1220 Infinity LC System Performance Specifications Diode Array Detector (G4294B only)
    Detector type 1024-element diode array
    Light source Deuterium and tungsten
    Number of signals 8
    Maximum sampling rate 80 Hz
    Short-term noise < ± 0.7 x 10-5 AU at 254/4 nm and at 750 nm, TC 2 s
    Drift < 0.9 x 10-3 AU/hr at 254 nm
    Linearity > 2.0 AU (5 %) at 265 nm
    Wavelength range 190-950 nm
    Wavelength accuracy ± 1 nm, self-calibration with deuterium lines verification with holmium oxide filter
    Slit width Programmable: 1, 2, 4, 8, 16 nm
    Diode width < 1 nm

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