Dissolution 

Dissolution Apparatus 

400-DS Apparatus 7 
Product Description
The Agilent 400-DS Dissolution Apparatus 7 sets the performance standard for small-volume drug-release testing of medical devices such as drug eluting stents (DES). A variety of standard and custom holders are available for testing of combinatorial products, pacemaker leads, contact lenses, catheters, wound care products, extractables, leachables and more.

It is the first dissolution apparatus built specifically for small-volume dissolution testing of combination drug products that meets all compendial requirements for USP Apparatus 7. The 400-DS complies with 21 CFR Part 11 guidelines and brings an unprecedented level of convenience, throughput, and efficiency to your quality control and R&D operations.

Take a look at our 400-DS webinar recording for more information on this small-volume testing product.
  • Performs automated small-volume dissolution testing using as little as 3 mL media volume in either 5 or 10 mL sample cells
  • Saves time by simultaneously testing up to 13 samples, or 12 samples and a control or standard, while providing users direct visibility of each dissolution cell
  • Maintains temperature control through internal temperature probes and external heating jackets; no water bath is required
  • Minimizes evaporation through the fully closed system
  • Integrated syringe pump and autosampler save valuable bench space
  • Offers automated media addition/removal of up to 5 different types of media through a port on the bottom of the cell
  • Enables sample holder reciprocation through an externally controlled magnetic plate and supports between 1 and 35 dips per minute (DPM) to best match your requirements
  • Accommodates 12 individual sample rows with either 2 or 4 mL HPLC vials for unattended sample collection
  • Allows you to program up to 36 timepoints and five different media types into a method; software prompts for the removal and replacement of the racks during the run
  • Automates full or partial media replacement at each timepoint via a built-in fluidics module for each sample cell
  • 21 CFR Part 11 compliant software and a single PC can independently control up to four 400-DS systems
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