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Using Dried Blood Spots in Combination with UHPLC and Enhanced Ion Generation ESI to Streamline Pharmacokinetic Assays

Abstract: This application note demonstrates the productivity performance of the Agilent 1290 Infinity LC coupled to the Agilent 6460A Triple Quadrupole LC/MS. The following will be shown: • Use of dried blood spot (DBS) technology to extract a cassette of pharmaceuticals from merely 15 μL of full blood • High speed chromatography / MS at column back pressures approaching 1,200 bar using a novel ZORBAX Rapid Resolution High-Definition (RRHD) sub-2 μm particle column • High quality separation of a cocktail of seven small molecule drugs in less than 50 sec • High-end detection sensitivity

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