Online literature is provided as Adobe Acrobat Portable Document Format (PDF) files.
Obtain your free copy of the current
Acrobat Reader from Adobe Systems.
Analysis of PAMPA samples using the Agilent 1200 Series RRLC system with an Agilent 6460 Triple Quadrupole LC/MS system
Abstract:
In this Application Note an Agilent 1200 Series Rapid Resolution LC system coupled to an Agilent 6460 Triple Quadrupole LC/MS system was used for the analysis of parallel
artificial membrane permeability assay (PAMPA) samples, each containing four target compounds. The MassHunter Optimizer software was used to identify the most intense product ions, optimal fragmentor voltages and collision energies. The apparent permeability values of ten pharmaceutical compounds belonging to four different
classes of drugs were determined.
Keywords:
1200, RRLC, Rapid Resolution, 6460, QQQ, triple quad, quadrupole, LC/MSartificail membrane permeability assay, PAMPA, MassHunter optimization software, software
Publication Number:
5990-4878EN
Last Updated:
10/26/2009
Number of Pages:
4
View Article
(0.31 MB)