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An Application Kit for the Screening of Samples for Analytes of Forensic and Toxicological Interest using LC/QQQ MS/MS with a Dynamic MRM Transition Database

Abstract: A Forensic and Toxicological screening application kit has been developed for use with the Agilent 6400 Series triple quadrupole (QQQ) LC/MS systems which contains a database of optimized MRM transitions for approximately 200 analytes of forensic and toxicological interest. The database content is mainly focused on controlled substances and drugs of abuse. The aim of this application kit is to provide a user with a solid starting point for building analysis methods where the ability to screen for a large array of forensic and toxicological analytes is necessary. Typical results obtained from such a method created by using the database are described using serial dilutions of a test mix containing analytes of forensic interest.

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