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Screening Impurities in Fine Chemicals Using the Agilent 1290 Infinity LC System
Abstract:
The Agilent 1290 Infinity LC System with ultra violet/visible (UV/VIS) Diode Array detection (DAD) is used to analyze octyl-dimethyl-p-aminobenzoic acid for the presence
of impurities. The system is used for the chromatographic separation of the compound from its impurities on 3.0 and 2.1 mm id C18 columns, of various lengths,
with 1.8-um packing materials prepared in 600-bar (9000 psi) or special 1200-bar (18,000 psi) configurations. The ability of the 1290 Infinity LC System to operate with
long, high resolution columns under conditions of rapid analysis is demonstrated with low viscosity acetonitrile (ACN) and higher viscosity methanol (MeOH) solvent conditions.
Keywords:
HPLC, RRLC, UHPLC, fine chemical, impurity, Infinity, 1290, viscosity, RRHT, RRHD, organic chemicals
Publication Number:
5990-4293EN
Last Updated:
11/5/2009
Number of Pages:
10
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