Online literature is provided as Adobe Acrobat Portable Document Format (PDF) files. Obtain your free copy of the current Acrobat Reader from Adobe Systems.

The Comparative Evaluation of TargetNon-Target Screen and Quantitation Techniques of 224 Pesticides in Potable Water WPY 594

Abstract: Environmental watchdog communities across the world are looking ever-increasingly to the routine screening of potable water supplies for pesticide residues. An example of this is the European Water Framework Directive, which has been under discussion since 2001. Here the feasibility of LC/MS screening approaches are currently at a consultation level. Localized legislation such as that prescribed by the UK Drinking Water Inspectorate requires that challenging pesticide concentration levels are monitored and that sample levels should contain no higher than 100ppt of an individual pesticide and no more than 500ppt in totality. Validated and reliable means are therefore required to detect pesticides at 10x lower amounts than the prescribed limit (10ppt) for quantitative purposes. Here we present two screening approaches target/non-target with their respective merits. Levels of pesticides remain significant in drinking water supplies even after filtration processes so it is important to obtain reliable low-level (pg/fg) reporting of positives with routine screening techniques prior to absolute quantitation. LC/MS offers the best solution for screening of drinking water matrix for pesticide residues, and this work compares an accurate mass ‘unknown and unlimited’ screening technique using Time of Flight (TOF) MS instruments with a target analysis approach for a suite of 250 pesticides using highly sensitive QqQ tandem MS with dynamic multi reaction monitoring (dynamic MRM.)

View Article (1.17 MB)

For your convenience this PDF file will open in a separate window, and you may need to adjust your pop up blocker setting.