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Dynamic MRM Method Optimization for UHPLC-QQQ Multi-Residue Analytical Applications

Abstract: Ultra High Performance Liquid Chromatography (UHPLC) is enabling efficient, high peak capacity separations which are finding increased relevance in complex, multi-residue analytical applications. As the need and challenge to rapidly analyze large numbers of analytes has grown, MRM methods with multiple time segments have been developed to reduce the scan cycle time and number of concurrent MRMs. These methods, however, have several critical limitations when applied to complex samples (e.g. several hundred pesticides). Dynamic MRM acquisition provides triple quad users with a new and rapid means to develop well-optimized multi-analyte LC/MS/MS methods. Utilizing analyte retention times, detection windows (Delta RT), and a constant scan cycle time, DMRM software automatically constructs DMRM timetables for the precise detection of multiple analytes as they chromatographically elute.

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