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Development of a method for separation of the four stereoisomers of troglitazone using capillary electrophoresis

Abstract: Troglitazone, a mixture of four stereoisomers, is effective in both non-insulin and insulin dependent diabetes mellitus. As the pharmacodynamic activities of drug enantiomers may differ drastically, there is a need for a reliable and accurate method to separate the stereoisomers. Troglitazone was best resolved by using CD-MEKC with SDS and Heptakis (2,3,6-tri-Omethyl)--cyclodextrin dissolved in borate buffer pH 9.4. The CE analysis is less expensive; there is less organic waste, resolution is improved and run time reduced compared to HPLC.

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