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EPA Method 1694: Agilent's 6410A LC/MS/MS Solution for Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biomass

Abstract: An analytical methodology for screening and confirming the presence of 65 pharmaceuticals in water samples was developed using the Agilent G6410A Triple Quadrupole mass spectrometer (QQQ). The method was developed following the guidelines in EPA Method 1694. Four distinct chromatographic gradients and LC conditions were used according to the polarity and extraction of the different pharmaceuticals. Positive and negative ion electrospray were used with two multi-reaction monitoring (MRM) transitions (a quantifier and a qualifier ion for each compound), which adds extra confirmation in this methodology compared with the EPA method. Linearity of response of three orders of magnitude was demonstrated (r2 > 0.99) for all the pharmaceuticals studied. The analytical performance of the method was evaluated for one wastewater sample collected from Boulder Creek, Colorado; positive identifications for carbamazepine and diphenhydramine were found for this sample using the methodology developed in this work.

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