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Development and validation of an HPLC method to analyze ibuprofen and impurities according to the European Pharmacopoeia using the Agilent 1120 Compact LC
Abstract:
This Application Note describes the development of a fast, accurate, and reproducible method to analyze ibuprofen and related impurities according to European Pharmacopoeia (EP) regulations1, using an Agilent 1120 Compact LC. The experiments described in this Application Note include determination of precision of areas and retention times, as well as chromatographic parameters like resolution and signal-to-noise ratios. The experiments prove precise results from a system that was optimized for everyday productivity, and they fulfill regulatory compliance.
Keywords:
1120 Compact LC; EZChrom Elite Compact software; ibuprofen; active pharmaceutical ingredients (APIs); ZORBAX SB-C18; ibuprofen and related impurities; pharmaceutical testing in QA/QC
Publication Number:
5989-9241EN
Last Updated:
8/25/2008
Number of Pages:
4
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