Online literature is provided as Adobe Acrobat Portable Document Format (PDF) files.
Obtain your free copy of the current
Acrobat Reader from Adobe Systems.
Assessment of in-process impurities in pravastatin using the Agilent 6410 TripleQuadrupole LC/MS in negative mode
Abstract:
In-process impurities from pravastatin were separated using an Agilent ZORBAX Eclipse XDB-C18 column with 1.8 μm particle size and were determined using the Agilent 6410 Triple Quadrupole LC/MS system. Neutral and precursor ions scans were performed at specific time segments during the LC/MS run. At the elution time of the main peak, the diverter valve was switched to waste, thereby eliminating interference from the main drug peak during analysis. Both neutral loss and precursor ion scans were used to determine possible unknown impurities.
Keywords:
6410 Triple Quadrupole LCMS system; 1200 Series Rapid Resolution LC; RRLC; ZORBAX Eclipse XDB-C18 column; MassHunter Workstation software; pharmaceutical impurity analysis; in-process impurities; pravastatin; active pharmaceutical ingredients; APIs; HPLC; 1200 Series binary pump SL; 1200 Series diodearray detector; DAD; impurity profiling
Publication Number:
5989-9343EN
Last Updated:
8/22/2008
Number of Pages:
8
View Article
(0.28 MB)