High resolution Diffusion-Ordered Spectroscopy is a very efficient tool for obtaining structural information on mixtures of small and medium size molecules. Unlike other physical methods used for mixture analysis, or NMR combined with liquid chromatography and/or mass spectrometry, DOSY does not require a physical separation technique. Accurate determination of the diffusion coefficients enables visual distinction of mixture components in NMR spectra, or may serve as an experimental basis for predicting hydrodynamic radii and therefore molecular weights. Diffusion data are also often used to monitor solution-state aggregation or binding between ligands and macromolecules.
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