The super-quiet CryojetXL by Oxford Instruments is an open flow nitrogen gas blower that is compatible with all of Agilent’s X-ray diffractometers and can be controlled and programmed remotely via the CrysAlisPro software. It can cool crystal samples and maintain temperatures between 90 and 300 Kelvin, with no risk of icing or nozzle blockages, thanks its innovative design. The device has a large cooling volume which can be supplemented with the optional Autofill system that replenishes the device’s liquid nitrogen dewar during extended cryo experiments.