The Agilent RapidFire 300 High-throughput Mass Spectrometry System adds unattended sample processing and flexible plate mapping to the RapidFire instrument portfolio. With an automated cartridge changer and integrated optical sensors, RapidFire 300 High-throughput Mass Spectrometry enables unattended overnight operation and automatically detects fluid flow. The RapidFire 300 High-throughput Mass Spectrometry was designed to meet investigators’ demand for high quality data with a short turnaround time. It fully integrates with leading triple quadrupole mass spectrometers and provides data compatible with existing laboratory information management systems.