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Challenging Drug Targets Now HTS-Enabled with RapidFire 

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Example Applications of the RapidFire System for Drug Discovery 

Using RapidFire technology, organizations have gained new insights into drug targets that they never would have attempted in the past — either because it would be too costly, time consuming, or difficult to obtain reliable data.

Below is just a sampling of the applications for which RapidFire technology has been used either by or for our collaborators. Many of these studies are published in scientific journals.

KINASES  ONCOLOGY 
  • Protein kinases (ATK1/PKBa, Lck Kinase)

  • Protein hydroxylases (FIH)
  • Phosphatidylserine decarboxylase
INFLAMMATION / PAIN ANTI-INFECTIVES
  • Fatty acid amide hydrolase

  • Lipoxygenases (5-LOX, 15-LOX)
  • UDP-3-O(R-3-hydroxymyristoyl)-deacetylase  [LpxC] 
CARDIOVASCULAR DISEASE NEUROLOGY 
  • Phosphatidylethanolamine N-methyltransferase

  • Phospholipase A2

  • Cystathioninesynthase
  • Phytanoyl-CoA hydroxylase

  • Acetylcholinesterase 
EPIGENETICS METABOLIC DISORDER / DIABETES
  • Histone de-acetylases (sirtuins, HDACs)

  • Protein methylases/demethylases (LSD-1)

  • Histone Acetyltransferases (HATs)
  • 11b-hydroxysteroid dehydrogenase

  • Diacylglycerolacyltransferase

  • Stearoyl-CoA desaturase

  • GM3 synthase

  • Acetyl-CoA carboxylase

  • Serine palmitoyltransferase

  • ATP citrate lyase

 
 
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