Assays that measure plasma protein binding (PPB) are used to predict pharmacokinetic profiles early in drug discovery to eliminate poor performers and/or to identify compounds that require modification. Mass spectrometry is the preferred analysis method for these assays due to its sensitivity, specificity and robustness.
However, PPB assays are usually analyzed using tandem MS, which is limited by its requirement for compound dependent method development. Using the RapidFire High-throughput TOF system, Agilent in-house scientists perform PPB assay analysis faster and more efficiently, enabling us to turnaround your data in just three (3) days.