Olignucleotide Analysis
The analysis of oligonucleotides or antisense oligonucleotide
therapeutics by capillary electrophoresis can be fast, reproducible
and highly automated. This makes it ideally suitable for quality
control applications in oligonucleotide core facilities, as well
as in many phases of biopharmaceutical drug development.
The Application Note "Oligonucleotide
Analysis with the Agilent Capillary Electrophoresis System"
(publication number 5988-4303EN) lists everything needed to
analyze short oligonucleotides of DNA and RNA, and antisense oligonucleotides.
In addition, single-stranded and double-stranded oligonucleotides
can be analyzed in a single run. It describes
how to use the Agilent Capillary Electrophoresis System and chemicals
from 3rd party vendors for oligonucleotide analysis.
Application Literature