Laboratories using headspace (HS) GC for the analysis of pharmaceutical impurities face a number of instrument-related issues:
- Area precision in headspace analysis is impacted by atmospheric pressure changes
- Sensitivity is poor for some low-concentration analytes.
- Presence of high-boiling impurities noticeably extends the analysis time per sample and may damage the analytical column
In a study an established Agilent 6890N HS-GC/FID method for residual solvents analysis was directly transferred to the new Agilent 7890A GC without any method development or altering the performance. The results on both systems compared well.
With the new technology of the Agilent 7890A GC it was even possible to:
- Improve area precision by a factor of 3 to 5
- Double retention time repeatability,
- Enhance sensitivity by a factor of 2.
Finally, the backflush capability of the 7890A GC significantly reduced overall analysis time (in the example by 50 %).
In summary, it was demonstrated, that the Agilent 7890A GC delivers much better precision, sensitivity, and higher sample throughput than the Agilent 6890N GC.
Click here for detailed Application Note.
More Applications
While the experimental setup used in this application is suitable for the routine analysis of residual solvents, it does not provide any further information when unknowns are present. The solution is to couple the GC to a mass-selective detector (MSD), such as the Agilent 5975B Series MSD. Then you can achieve superior results for both identification of unknowns and quantitation of target compounds. Click here for more details.
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