Groton Biosystems Automated Reactor Sampling (ARS) System and the Agilent 1200 Series LC System
The Groton Biosystems Automated Reactor Sampling (ARS) system and the Agilent 1200 Series LC system automate sampling and analysis of amino acids and proteins and provide a closed-loop system for monitoring reactor nutrients to optimize product yields.
What is the driving force behind online HPLC analysis in the biopharmaceutical industry?
HPLC is a workhorse analytical tool in the pharmaceutical and biotechnology industries. The ability to bring the Agilent 1200 Series LC closer to the production process, providing near real time data, has been desperately needed and requested by many major companies and is in alignment with the FDA's Process Analytical Technologies (PAT) Initiative.
Why is this important for decision makers in the pharmaceutical industry?
Pharmaceutical industry executives are under pressure to reduce the cost of drugs while at the same time ensuring the highest possible level of quality. This online HPLC solution with the Agilent 1200 Series LC reduces the amount of expensive manual labor in the development and manufacturing processes. At the same time it eliminates the chance of human error and increases the speed of analysis.
What will Agilent Technologies and Groton Biosystems be doing to make PAT solutions available to their mutual customers?
Agilent Technologies and Groton Biosystems will be collaborating on marketing activities as well as making joint sales calls, promoting the Groton Biosystems Automated Reactor Sampling (ARS) system and the Agilent 1200 Series LC specifically for online HPLC assays to the major biotechnology companies. The product moves the traditional bench-top analytical HPLC system closer to the method development and/or production operation.
What is the advantage of rapid, quality-related decision-making?
The Agilent 1200 Series LC online solution provides near real time analytical data on the manufacturing process parameters by having the analytical instrument connected directly to the production process stream (bioreactor). Traditional techniques involved manual sampling and delivery to an analytical lab located offsite. This powerful new tool provides the ability to make quick process adjustments, which will increase yield and provide consistent high quality products for cell culture and fermentation applications.
What does a state-of-the-art online sampling system mean in real terms for the customer?
Groton Biosystems has developed the ARS Automated Reactor Sampling system, which connects directly to any liquid process stream. The ARS pulls samples directly from the process stream, performs sample preparation when necessary, and then delivers the sample to the Agilent 1200 Series LC System as well as other analytical instruments as required.
How will the ARS eliminate human intervention in online sample acquisition and what are the benefits?
The system does not require a human to pull, prepare and log samples manually from a method development or pilot production process. The ARS draws sample automatically and delivers it to the Agilent 1200 Series LC system. The LC system is programmed to analyze the sample once it is delivered. The major benefit of this solution is the ability to sample online 24 hours a day, 7 days a week.
For further information, download the product brochure
Transfer to Groton Biosystems website.